PHOTOCHEMICAL CLEAVAGE OF OLIGONUCLEOTIDES FROM SOLID-PHASE SUPPORTS

被引：16

作者：

GREENBERG, MM

机构：

[1] Department of Chemistry, Colorado State University, Fort Collins

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 02期

关键词：

D O I：

10.1016/S0040-4039(00)60559-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5'-O-Dimethoxytrityl-3'-O-succinatothymidine is covalently, linked to long chain alkyl amine controllled pore glass support (LCAA-CPG) via an o-nitrobenzyl group. The modified solid phase synthesis support is compatible with standard automated phosphoramidite based oligonucleotide synthesis. Cleavage from the solid support is achieved via CuSO4 filtered photolysis. Isolated yields are comparable with those obtained from other oligonucleotide supports.

引用

页码：251 / 254

页数：4

共 21 条

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