CLONAL EXPANSION OF HYPERMUTATED MEASLES-VIRUS IN A SSPE BRAIN

被引：104

作者：

BACZKO, K

LAMPE, J

LIEBERT, UG

BRINCKMANN, U

TERMEULEN, V

PARDOWITZ, I

BUDKA, H

COSBY, SL

ISSERTE, S

RIMA, BK

机构：

[1] MAX PLANCK INST EXPTL MED,W-3400 GOTTINGEN,GERMANY

[2] QUEENS UNIV BELFAST,DIV MOLEC BIOL,BELFAST BT9 7BL,ANTRIM,NORTH IRELAND

[3] UNIV VIENNA,INST NEUROL,A-1010 VIENNA,AUSTRIA

来源：

VIROLOGY | 1993年 / 197卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/viro.1993.1579

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nucleotide sequence analysis was carried out to study genes encoding the matrix (M) protein of measles virus (MV) from several regions of the brain of a case of subacute sclerosing panencephalitis. This analysis revealed the presence of MV with "wild-type" sequences as well as variants which had undergone at least five biased hypermutation events (U to C and A to G in the positive strand sequences). Despite the presence of MV variants with genes encoding the intact matrix protein open reading frame, M protein could not be detected in any of the brain regions. The distribution of virus variants was studied by cDNA cloning and sequence analysis and by in situ hybridization. The hypermutated viruses appeared to expand clonally throughout the brain of patient B. © 1993 Academic Press. All rights reserved.

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页码：188 / 195

页数：8

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