PROTEOLYTIC DEGRADATION OF HEMOGLOBIN IN ERYTHROCYTES LEADS TO BIOLOGICALLY-ACTIVE PEPTIDES

被引：59

作者：

KARELIN, AA

PHILIPPOVA, MM

IVANOV, VT

机构：

[1] Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117871 Moscow, ul. Miklukho-Maklaya 16/10

来源：

PEPTIDES | 1995年 / 16卷 / 04期

关键词：

HEMOGLOBIN; HUMAN; PEPTIDE FRAGMENTS; NEO-KYOTORPHIN; PRECURSOR; HPLC; ISOLATION;

D O I：

10.1016/0196-9781(95)00029-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of hemoglobin-derived homogenous peptides were isolated from erythrocyte lysate. The amino acid sequences of nine peptides were determined. Seven out of nine peptides were relatively long, 30-32 membered peptides covering the N- or C-terminal sequences of globin chains. The remaining two were the pentapeptide neo-kyotorphin and its tetrapeptide derivative.

引用

页码：693 / 697

页数：5

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