A synthetic approach to (+)-dioncophylline C

被引：13

作者：

Gable, RW ^{[1
]}

Martin, RL ^{[1
]}

Rizzacasa, MA ^{[1
]}

机构：

[1] UNIV MELBOURNE,SCH CHEM,PARKVILLE,VIC 3052,AUSTRALIA

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1995年 / 48卷 / 12期

关键词：

D O I：

10.1071/CH9952013

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In a synthetic approach to (+)-dioncophylline C (1), a coupling between the chiral oxazoline (3) and the Grignard reagent obtained from bromide (4) gave the major biaryl (5) and the minor biaryl (12) in good yield and high diastereoselectivity (yield 70%; ratio 91:9). The stereochemistry of the major biaryl (5) was confirmed by X-ray structure analysis of the derived crystalline iodide salt (13).

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页码：2013 / 2021

页数：9

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