CONCOMITANT IMMUNITY IN HAMSTERS BEARING DMBA-INDUCED TUMOR TRANSPLANTS

Hamsters bearing progressively growing DMBA‐induced tumor transplants were found to make a specific immune response to the neoplasm. This response was identified because animals bearing DMBA tumors rejected concentrations of DMBA‐transformed cells that were capable of inducing tumors in normal animals. This concomitant immunity was detectable even when the immunizing and challenge cells were inoculated simultaneously. Animals bearing DMBA‐induced tumor cell transplants were not protected against challenge with hamster cells transformed by simian papovavirus SV40, confirming the specificity of the concomitant immunity being studied. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company