THE EFFECT OF MK-801 ON THE MICTURITION REFLEX IN ANESTHETIZED RATS

被引：39

作者：

MAGGI, CA

GIULIANI, S

GIACHETTI, A

MELI, A

机构：

[1] Pharmacology Department, A. Menarini Pharmaceuticals, Florence, 50131

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 181卷 / 1-2期

关键词：

(Rat); Bladder voiding; Micturition reflex; MK-801; NMDA receptors;

D O I：

10.1016/0014-2999(90)90250-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We studied the effect of MK-801, a potent non-competitive NMDA receptor antagonist, on the micturition reflex in anesthetized rats. Pretreatment with MK-801 (0.1-1 mg/kg i.v.) dose dependently increased the bladder capacity and reduced the micturition contraction. The ability of MK-801 to inhibit bladder voiding was confirmed in additional experiments in which the compound (30-50 μg/kg i.v.) transiently suppressed established bladder voiding produced by continuous bladder filling. MK-801 (1 μM) did not affect nerve-mediated contractions of the rat bladder or inhibit the response to capsaicin. These findings provide pharmacological evidence for an involvement of NMDA receptors in the micturition reflex pathways. © 1990.

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页码：105 / 109

页数：5

相关论文

共 24 条

[1] BARORECEPTOR-VASOMOTOR REFLEX AFTER N-METHYL-D-ASPARTATE RECEPTOR BLOCKADE IN RABBIT CAUDAL VENTROLATERAL MEDULLA [J].

BLESSING, WW .

JOURNAL OF PHYSIOLOGY-LONDON, 1989, 416 :67-78

[2]

BOWERY NG, 1988, BRIT J PHARMACOL, V93, P994

[3] ANTICONVULSANT ACTIVITY OF (+)-5-METHYL-10, 11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5, 10-IMINE (MK-801), A SUBSTANCE WITH POTENT ANTICONVULSANT, CENTRAL SYMPATHOMIMETIC, AND APPARENT ANXIOLYTIC PROPERTIES [J].

CLINESCHMIDT, BV ;

MARTIN, GE ;

BUNTING, PR .

DRUG DEVELOPMENT RESEARCH, 1982, 2 (02) :123-134

[4] THE NOVEL ANTICONVULSANT MK-801 BINDS TO THE ACTIVATED STATE OF THE N-METHYL-D-ASPARTATE RECEPTOR IN RAT-BRAIN [J].

FOSTER, AC ;

WONG, EHF .

BRITISH JOURNAL OF PHARMACOLOGY, 1987, 91 (02) :403-409

[5] NEUROBIOLOGY - TAKING APART NMDA RECEPTORS [J].

FOSTER, AC ;

FAGG, GE .

NATURE, 1987, 329 (6138) :395-396

[6]

KAMEI J, 1989, EUR J PHARMACOL, V168, P153

[7] AGONISTS, ANTAGONISTS AND MODULATORS OF EXCITATORY AMINO-ACID RECEPTORS IN THE GUINEA-PIG MYENTERIC PLEXUS [J].

LUZZI, S ;

ZILLETTI, L ;

FRANCHIMICHELI, S ;

GORI, AM ;

MORONI, F .

BRITISH JOURNAL OF PHARMACOLOGY, 1988, 95 (04) :1271-1277

[8] EVIDENCE FOR THE INVOLVEMENT OF ENDOGENOUS SUBSTANCE-P IN THE MOTOR EFFECTS OF CAPSAICIN ON THE RAT URINARY-BLADDER [J].

MAGGI, CA ;

SANTICIOLI, P ;

MELI, A .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1985, 37 (03) :203-204

[9] THE ROLE OF THE CAPSAICIN-SENSITIVE INNERVATION OF THE RAT URINARY-BLADDER IN THE ACTIVATION OF MICTURITION REFLEX [J].

MAGGI, CA ;

SANTICIOLI, P ;

BORSINI, F ;

GIULIANI, S ;

MELI, A .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1986, 332 (03) :276-283

[10] DERMORPHIN INHIBITS MICTURITION REFLEX IN RATS AT A CENTRAL SITE OF ACTION [J].

MAGGI, CA ;

GIULIANI, S ;

MELI, A .

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1989, 26 (01) :11-16