EVOLUTION OF PHENOTYPIC MEMORY T-CELLS IN HIV-1 INFECTED INFANTS AND CHILDREN

被引：16

作者：

BORKOWSKY, W ^{[1
]}

MOORE, T ^{[1
]}

KRASINSKI, K ^{[1
]}

AJUANGSIMBIRI, KO ^{[1
]}

HOLZMAN, R ^{[1
]}

机构：

[1] NYU MED CTR,DEPT MED,NEW YORK,NY 10016

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1992年 / 63卷 / 03期

关键词：

D O I：

10.1016/0090-1229(92)90234-F

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infants are reported to be devoid of memory T cells at birth but acquire them with time. A cross-sectional study of peripheral blood mononuclear cells from HIV-infected and uninfected infants and children that bear the CD4R0 anti-gen was undertaken to describe the development of memory T cells. Linear regression lines derived from the data revealed increasing percentages of memory CD4 and CD8 cells in the uninfected children. Memory CD4 cells in the infected children were detected at a frequency equal to or greater than that seen in uninfected children until 6 months of age but subsequently declined with age. In contrast, memory CD8 cells were found to be significantly increased in HIV-infected children early in life with a rate of increase similar to that seen in the uninfected population. This increase in memory CD8 cells may facilitate the early diagnosis of HIV infection. © 1992.

引用

页码：280 / 284

页数：5