MOLECULAR-BIOLOGY OF OPIOID RECEPTORS

被引:317
作者
REISINE, T
BELL, GI
机构
[1] UNIV CHICAGO,HOWARD HUGHES MED INST,CHICAGO,IL 60637
[2] UNIV CHICAGO,DEPT BIOCHEM & MOLEC BIOL,CHICAGO,IL 60637
关键词
D O I
10.1016/0166-2236(93)90194-Q
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Opium and its derivatives are potent analgesics that also have many other pharmacological effects in the nervous system. These agents and the endogenous opioid peptides exert their effects by interacting with high-affinity receptors. Complementary DNAs encoding the delta, kappa and mu opioid receptors have been isolated and characterized. These receptors, which are members of the superfamily of seven-transmembrane spanning receptors, share a high degree of amino acid sequence similarity with approximately 50% of the residues being identical. The cloned opioid receptors mediate agonist inhibition of cyclic AMP formation and have pharmacological properties similar to the endogenous proteins. The cloning of these receptors will facilitate the development of new clinically useful compounds as well as studies of the molecular basis of tolerance and drug addiction.
引用
收藏
页码:506 / 510
页数:5
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