IMPROVED COLUMN-SWITCHING LIQUID-CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF THE ENANTIOMERS OF MEFLOQUINE

被引：13

作者：

GIMENEZ, F

DUMARTIN, C

WAINER, IW

FARINOTTI, R

机构：

[1] UNIV PARIS 11,FAC PHARM,DEPT PHARM CLIN,F-92290 CHATENAY MALABRY,FRANCE

[2] MCGILL UNIV,DEPT ONCOL,MONTREAL H3A 2T5,QUEBEC,CANADA

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 619卷 / 01期

关键词：

D O I：

10.1016/0378-4347(93)80461-C

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A liquid chromatographic method for the determination of the enantiomers of mefloquine has been improved. The chromatography involved two columns: an achiral cyanopropyl stationary phase for the quantification of (+/-)-mefloquine and a chiral naphthylurea stationary phase for the determination of the enantiomeric ratio. Compared with the previous method, which needed two detectors, this one used one detector-integrator to which the two columns are connected alternately by an automated column-switching system. The method is suitable for the quantification (0.05 mug/ml) of mefloquine and the determination of enantiomeric ratios from 500-mul plasma samples with ultraviolet detection.

引用

收藏

页码：161 / 166

页数：6

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