INVITRO ACTIVITY OF CHLOROQUINE AND QUININE IN COMBINATION WITH DESFERRIOXAMINE AGAINST PLASMODIUM-FALCIPARUM

被引：6

作者：

BASCO, LK

LEBRAS, J

机构：

[1] Centre National de Référence pour la Chimiosensibilité du Paludisme, Institut de Médecine et d'Epidémiologie Tropicales, Laboratoire de Parasitologie, Paris

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1993年 / 42卷 / 04期

关键词：

MALARIA; ANTIMALARIAL DRUGS; QUINOLINE COMPOUNDS;

D O I：

10.1002/ajh.2830420411

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The activity of chloroquine and quinine, alone and in combination with desferrioxamine (7 mumol/liter), was evaluated in vitro against susceptible and resistant clones of Plasmodium falciparum by a semimicroassay system. The addition of desferrioxamine had no effect on the activity of chloroquine against both clones. Desferrioxamine had no effect on the activity of quinine against the susceptible clone but had slightly enhanced quinine action against the resistant clone. Further development of desferrioxamine as an antimalarial drug may be of limited interest.

引用

页码：389 / 391

页数：3

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