A SHORT SYNTHETIC ROUTE TOWARDS A BIOLOGICALLY-ACTIVE HEPARIN-LIKE PENTASACCHARIDE WITH A PSEUDO-ALTERNATING SEQUENCE

被引：17

作者：

LUCAS, H ^{[1
]}

BASTEN, JEM ^{[1
]}

KONRADSSON, P ^{[1
]}

VANBOECKEL, CAA ^{[1
]}

机构：

[1] AKZO,DIV PHARMA,ORGANON SCI DEV GRP,POB 20,5340 BH OSS,NETHERLANDS

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1993年 / 32卷 / 03期

关键词：

D O I：

10.1002/anie.199304341

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Simplification of the structure but maintenance of the biological activity-this (successful) strategy was the basis for the synthesis of 1, the ''non-glycosamino'' glycan analogue of the pentasaccharide domain of heparin responsible for binding antithrombin III. The disaccharide corresponding to the EF building block could be prepared from a protected derivative of fragment GH by base-catalyzed epimerization at C5. The number of synthetic steps was thus significantly reduced. [GRAPHICS]

引用

页码：434 / 436

页数：3

共 13 条

[11] SYNTHESIS OF TIGOGENYL BETA-O-CELLOBIOSIDE HEPTAACETATE AND GLYCOSIDE TETRAACETATE VIA SCHMIDT TRICHLOROACETIMIDATE METHOD - SOME NEW OBSERVATIONS
URBAN, FJ
MOORE, BS
BREITENBACH, R
[J]. TETRAHEDRON LETTERS, 1990, 31 (31) : 4421 - 4424
[12] SYNTHESIS OF A POTENT ANTITHROMBIN ACTIVATING PENTASACCHARIDE - A NEW HEPARIN-LIKE FRAGMENT CONTAINING 2 3-O-SULPHATED GLUCOSAMINES
VANBOECKEL, CAA
BEETZ, T
VANAELST, SF
[J]. TETRAHEDRON LETTERS, 1988, 29 (07) : 803 - 806
[13] SYNTHESIS OF A PENTASACCHARIDE CORRESPONDING TO THE ANTITHROMBIN-III BINDING FRAGMENT OF HEPARIN
VANBOECKEL, CAA
BEETZ, T
VOS, JN
DEJONG, AJM
VANAELST, SF
VANDENBOSCH, RH
MERTENS, JMR
VANDERVLUGT, FA
[J]. JOURNAL OF CARBOHYDRATE CHEMISTRY, 1985, 4 (03) : 293 - 321

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