UTILIZATION OF DIFFERENTIAL SCANNING CALORIMETRY AS A SCREENING TECHNIQUE TO DETERMINE THE COMPATIBILITY OF KETOPROFEN WITH EXCIPIENTS

被引：108

作者：

MURA, P

MANDERIOLI, A

BRAMANTI, G

FURLANETTO, S

PINZAUTI, S

机构：

[1] Dipartimento di Scienze Farmaceutiche, Università di Firenze, 50121 Firenze

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 119卷 / 01期

关键词：

KETOPROFEN; DSC; COMPATIBILITY; DRUG EXCIPIENT INTERACTION; SOLID DOSAGE FORM;

D O I：

10.1016/0378-5173(94)00374-E

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Differential scanning calorimetry (DSC) was used as a screening technique for assessing the compatibility of ketoprofen with some excipients currently employed in tablet or capsule formulations. The effect of sample treatment (simple blending, cogrinding, compression, kneading) was also evaluated. On the basis of DSC results, ketoprofen was found to be compatible with hydroxyethylcellulose? hydroxypropylcellulose. microcrystalline cellulose, corn starch, arabic gum, colloidal silica, veegum, lactose, glucose, sorbitol and mannitol. Some drug-excipient interaction was observed with palmitic acid, stearic acid and stearyl alcohol and eutectic formation was found with magnesium stearate. Strong solid-phase interaction with polyethylene glycol 6000, polyvinylpolypyrrolidone and even more with polyvinylpyrrolidone K30 was found.

引用

页码：71 / 79

页数：9

共 28 条

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STABILITY OF ASPIRIN IN SOLID MIXTURES [J].