COMPATIBILITY STUDY BETWEEN NAPROXEN AND TABLET EXCIPIENTS USING DIFFERENTIAL SCANNING CALORIMETRY

被引：51

作者：

BOTHA, SA

LOTTER, AP

机构：

[1] Research Institute for Industrial Pharmacy Potchefstroom University for C.H.E., Potchefstroom

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 04期

关键词：

D O I：

10.3109/03639049009104410

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Differential scanning calorimetry (DSC) was used to investigate the physico-chemical compatibility between naproxen and a number of commonly used tablet excipients. Interactions of naproxen with PVP, cross-linked PVP, Emcompress and the lubricants stearic acid, magnesium stearate and Precirol Ato 5 were found. Naproxen was found to be compatible with starch, Sta-Rx 1500, Primojel, Explotab, Avicel PH 101, Elcema G250, Ac-Di-Sol and Sterotex. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：673 / 683

页数：11

共 14 条

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