EFFECTS OF ANTINEOPLASTIC PHOSPHOLIPIDS ON PARAMETERS OF CELL-DIFFERENTIATION IN U937 CELLS

被引：51

作者：

HOCHHUTH, C ^{[1
]}

BERKOVIC, D ^{[1
]}

EIBL, H ^{[1
]}

UNGER, C ^{[1
]}

DOENECKE, D ^{[1
]}

机构：

[1] MAX PLANCK INST BIOPHYS CHEM,INST BIOCHEM,MOLEK BIOL ABT,W-3400 GOTTINGEN,GERMANY

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1990年 / 116卷 / 05期

关键词：

Antineoplastic phospholipids; cell differentiation; histone H10; U937; cells;

D O I：

10.1007/BF01612994

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The proliferation of the human promonocytic leukemia cell line U937 is inhibited by several ether lipids, ether lipid analogues and by phorbol esters. An early effect of this retardation of cell growth is the induction of a basic chromosomal protein, histone H10. Northern blot analysis of H10 mRNA levels reveals an increase of the mRNA concentration within a few hours after addition of hexadecylphosphocholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine. This early effect on the synthesis of a subtype of H1 proteins precedes the expression of several parameters of the monocytic differentiation of U937 cells. © 1990 Springer-Verlag.

引用

页码：459 / 466

页数：8

共 60 条

[11] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].

CHIRGWIN, JM ;

PRZYBYLA, AE ;

MACDONALD, RJ ;

RUTTER, WJ .

BIOCHEMISTRY, 1979, 18 (24) :5294-5299

[12] SYNTHESES AND MODULATIONS IN THE CHROMATIN CONTENTS OF HISTONE-H10 AND HISTONE-H1 DURING G1-PHASE AND S-PHASE IN CHINESE-HAMSTER CELLS [J].

DANNA, JA ;

GURLEY, LR ;

TOBEY, RA .

BIOCHEMISTRY, 1982, 21 (17) :3991-4001

[13] H-1 VARIANT SYNTHESIS IN PROLIFERATING AND QUIESCENT HUMAN-CELLS [J].

DINCALCI, M ;

ALLAVENA, P ;

WU, RS ;

BONNER, WM .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1986, 154 (02) :273-279

[14] DIFFERENTIAL DISTRIBUTION OF LYSINE AND ARGININE RESIDUES IN THE CLOSELY RELATED HISTONES-H1-DEGREES AND HISTONES-H5 - ANALYSIS OF A HUMAN H1-DEGREES GENE [J].

DOENECKE, D ;

TONJES, R .

JOURNAL OF MOLECULAR BIOLOGY, 1986, 187 (03) :461-464

[15]

EIBL H, 1981, LIPOSOMES PHYSICAL S, P19

[16]

EICK S, 1989, EUR J CELL BIOL, V49, P110

[17]

FALTYNEK CR, 1989, J IMMUNOL, V142, P500

[18]

GABRIELLI F, 1985, MOL CELL BIOCHEM, V65, P57

[19]

GAVISON R, 1988, ISRAEL J MED SCI, V24, P697

[20]

GEISSLER K, 1989, J IMMUNOL, V143, P140

← 1 2 3 4 5 6 →