HIGH-DOSE THIOTEPA WITH AUTOLOGOUS BONE-MARROW RESCUE IN RECURRENT MALIGNANT OLIGODENDROGLIOMA - A CASE-REPORT

被引:26
作者
SAARINEN, UM
PIHKO, H
MAKIPERNAA, A
机构
[1] Children's Hospital, University of Helsinki, Helsinki
关键词
autologous bone marrow transplantation; glioma; high grade; oligodendroglioma; thiotepa;
D O I
10.1007/BF00167069
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
High-dose thiotepa with autologous bone marrow rescue is a new and promising treatment modality in several kinds of solid tumors. We used this regimen in a pediatric patient who had the third recurrence of his malignant oligodendroglioma of brain that developed during '8 in 1' chemotherapy. We achieved complete response after a total dose of 1125 mg/m2 of intravenous thiotepa. Good penetration into the CNS renders thiotepa potentially useful for chemosensitive brain tumors, and one course of high-dose thiotepa can be administered with acceptable toxicity by utilizing autologous bone marrow rescue. © 1990 Kluwer Academic Publishers.
引用
收藏
页码:57 / 61
页数:5
相关论文
共 22 条
[11]  
HERZIG R, 1986, Proceedings American Society of Clinical Oncology Annual Meeting, V5, P126
[12]  
HERZIG R, 1988, P AN M AM SOC CLIN, V7, P74
[14]  
LAZARUS HM, 1987, CANCER TREAT REP, V71, P689
[15]   8 DRUGS IN ONE DAY CHEMOTHERAPY FOR BRAIN-TUMORS - EXPERIENCE IN 107 CHILDREN AND RATIONALE FOR PRERADIATION CHEMOTHERAPY [J].
PENDERGRASS, TW ;
MILSTEIN, JM ;
GEYER, JR ;
MULNE, AF ;
KOSNIK, EJ ;
MORRIS, JD ;
HEIDEMAN, RL ;
RUYMANN, FB ;
STUNTZ, JT ;
BLEYER, WA .
JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (08) :1221-1231
[16]   INTENSIVE 1,3-BIS (2-CHLOROETHYL)-1-NITROSOUREA (BCNU) MONOCHEMOTHERAPY AND AUTOLOGOUS MARROW TRANSPLANTATION FOR MALIGNANT GLIOMA [J].
PHILLIPS, GL ;
WOLFF, SN ;
FAY, JW ;
HERZIG, RH ;
LAZARUS, HM ;
SCHOLD, C ;
HERZIG, GP .
JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (05) :639-645
[17]  
SAARINEN UM, 1989, P AM SOC CLIN ONCOL, V8, P303
[18]  
STRANDJORD SE, 1987, 4TH ADV NEUR RES C P
[19]  
TRUMP DL, 1982, CANCER TREAT REP, V66, P1549
[20]  
ULTMANN JE, 1957, CANCER, V10, P902, DOI 10.1002/1097-0142(195709/10)10:5<902::AID-CNCR2820100507>3.0.CO