THE CLASSIFICATION OF CARCINOGENS IDENTIFIED IN THE RODENT BIOASSAY AS POTENTIAL RISKS TO HUMANS - WHAT TYPE OF SUBSTANCE SHOULD BE TESTED NEXT

被引：12

作者：

CLAYSON, DB ^{[1
]}

ARNOLD, DL ^{[1
]}

机构：

[1] HLTH & WELF CANADA,HLTH PROTECT BRANCH,FOOD DIRECTORATE,BUR CHEM SAFETY,DIV TOXICOL RES,OTTAWA K1A 0L2,ONTARIO,CANADA

来源：

MUTATION RESEARCH | 1991年 / 257卷 / 01期

关键词：

CLASSIFICATION OF CARCINOGENS; RODENT BIOASSAY DATA; REGULATORY AGENCIES; NEEDS OF; FOOD; HUMAN; CONSTITUENTS OF;

D O I：

10.1016/0165-1110(91)90020-V

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The relevance of rodent cancer bioassay data to humans is discussed in relation to the needs of regulatory agencies. The usefulness of in vivo and in vitro genotoxicity testing in this connection is also discussed. In the case of rodent carcinogens that do not elicit genotoxicity, it is suggested that homeostatic imbalance, cell proliferation, and other processes may play a major role in tumor development and its importance to the possible ability of the test agent to induce human cancer. These possibilities need to be evaluated on a case by case basis. The methods by which chemicals are selected for the rodent cancer bioassay are also discussed and it is pointed out that naturally-occurring constituents of human foods should in future receive greater priority as a consequence of anticipated changes resulting from biotechnology.

引用

页码：91 / 106

页数：16