NEGATIVE DOSE-RESPONSE RELATIONSHIP FOR RADIATION-INDUCED MICRONUCLEI IN POLYCHROMATIC ERYTHROCYTES OF MICE

被引：6

作者：

MCFEE, AF

COOK, SB

ABBOTT, MG

机构：

[1] Medical Sciences Division, Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee

[2] Bonner Springs, Kansas, 66012

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 1994年 / 23卷 / 02期

关键词：

CELL CYCLE DELAY; X-RAY; MICRONUCLEI; PCE;

D O I：

10.1002/em.2850230209

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Micronuclei were assessed among the bone marrow PCEs of mice 28 hr after exposures to 1 to 8 Gy of X-rays and at 6-hr intervals from 12-60 hr after exposures to 2 or 6 Gy. At 28 hr, the frequency of micronuclei declined as the exposure level increased from 1 to 8 Gy. The peak proportion of micronucleated PCEs appeared much later following 6 Gy than after 2 Gy exposures, implicating cell cycle delay as the cause of the negative dose-response relationship, (C) 1994 Wiley-Liss, Inc.

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收藏

页码：128 / 131

页数：4

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