CONTIGNASTEROL, A HIGHLY OXYGENATED STEROID WITH THE UNNATURAL 14-BETA CONFIGURATION FROM THE MARINE SPONGE PETROSIA-CONTIGNATA THIELE, 1899

被引：78

作者：

BURGOYNE, DL

ANDERSEN, RJ

ALLEN, TM

机构：

[1] UNIV BRITISH COLUMBIA,DEPT CHEM,VANCOUVER V6T 1Z4,BC,CANADA

[2] UNIV BRITISH COLUMBIA,DEPT OCEANOG,VANCOUVER V6T 1Z4,BC,CANADA

[3] UNIV ALBERTA,DEPT PHARMACOL,EDMONTON T6G 2H7,ALBERTA,CANADA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 02期

关键词：

D O I：

10.1021/jo00028a024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Contignasterol (1), a highly oxygenated steroid with the ''unnatural'' 14-beta proton configuration and a cyclic hemiacetal functionality in its side chain, has been isolated from the marine sponge Petrosia contignata. The structure of contignasterol was elucidated via spectroscopic studies of its tetraacetate 2 and its reduction product pentaacetate 5. Contignasterol (1) is the first example of a naturally occurring steroid with the ''unnatural'' 14-beta proton configuration.

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页码：525 / 528

页数：4

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