EFFECT OF TOTAL GASTRECTOMY ON REMNANT ISLET CELL-FUNCTION AFTER MAJOR PANCREATECTOMY IN RATS

被引：3

作者：

SHINAGAWA, Y

SUZUKI, T

机构：

[1] Department of Surgery II, Yamaguchi University School of Medicine, Ube, Yamaguchi

来源：

PANCREAS | 1992年 / 7卷 / 01期

关键词：

TOTAL GASTRECTOMY; ISLET CELL FUNCTION; PANCREATECTOMY;

D O I：

10.1097/00006676-199201000-00006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This study was designed to investigate the effect of total gastrectomy on remnant islet cell function after 85% distal pancreatectomy in rats. Eight-week-old Wistar male rats were divided into the following three groups: group 1, laparotomy; group 2, distal pancreatectomy; and group 3, distal pancreatectomy with total gastrectomy. Four weeks after the operation, i.v. glucose tolerance tests (ivGTT) were performed. The body weight in group 3 rats 4 weeks after the operation was significantly lower than that of the other two groups (p < 0.05). Glucose tolerance was impaired in both groups 2 and 3; group 3 was more impaired than group 2. Immunoreactive insulin (IRI) concentration in both groups 2 and 3 was much lower than that in group 1 throughout the ivGTT. Furthermore, IRI concentration in group 3 was lower than group 2 at all times. The integrated secretion of insulin for the 45 minutes after glucose injection was lower in group 3 than in group 2. It is concluded that total gastrectomy injures remnant pancreatic endocrine function after 85% distal pancreatectomy in rats.

引用

页码：30 / 33

页数：4

共 13 条

[11]

Santeusanio F., Faloona G.R., Unger R.H., Suppressive effect of secretin upon necrotic alpha cell function, J Clin Invest, 51, pp. 1743-1749, (1972)

[12]

Rehfeld J.F., Stadil F., The effect of gastrin on basal-and glucose-stimulated insulin secretion in man, J Clin Invest, 52, pp. 1415-1426, (1973)

[13]

Lolomon T.E., Morisset J., Wood H.G., Bussjaeger L.J., Additive interaction of pentagastrin and secretin on pancreatic growth in rats, Gastroenterology, 92, pp. 429-435, (1987)

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