ANTIBIOTIC-ACTIVITY AND ABSOLUTE-CONFIGURATION OF 8S-HEPTADECA-2(Z),9(Z)-DIENE-4,6-DIYNE-1,8-DIOL FROM BUPLEURUM-SALICIFOLIUM

被引：21

作者：

ESTEVEZBRAUN, A ^{[1
]}

ESTEVEZREYES, R ^{[1
]}

MOUJIR, LM ^{[1
]}

RAVELO, AG ^{[1
]}

GONZALEZ, AG ^{[1
]}

机构：

[1] UNIV LA LAGUNA,DEPT MICROBIOL & BIOL CELULAR,E-38206 TENERIFE,SPAIN

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 08期

关键词：

D O I：

10.1021/np50110a009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A polyacetylene has been isolated from Bupleurum salicifolium. Its structure and absolute configuration were determined to be 8S-heptadeca-2(Z),9(Z)-diene-4,6-diyne-1,8-diol [1] by means of H-1- and C-13-nmr spectroscopic studies, including (H)-C-13 heteronuclear correlation (HMQC) and long-range correlation spectra with inverse detection (HMBC). Its absolute configuration was determined by application of the Horeau method. This compound exhibited significant antibiotic activity against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis. Also isolated during this investigation were the known compounds: betulin, herniatin, 6,7,8-trimethoxycoumarin, p-hydroxyphenethyl alcohol, pluviatolide, guamaroline, bursehernin, guayadequiol, kaerophyllin, and matairesinol dimethyl ether.

引用

页码：1178 / 1182

页数：5

共 17 条

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