MECHANISM OF NORADRENALINE-INDUCED HETEROLOGOUS DESENSITIZATION OF ADENYLATE-CYCLASE STIMULATION IN RAT-HEART MUSCLE-CELLS - INCREASE IN THE LEVEL OF INHIBITORY G-PROTEIN ALPHA-SUBUNITS

被引:126
作者
REITHMANN, C [1 ]
GIERSCHIK, P [1 ]
SIDIROPOULOS, D [1 ]
WERDAN, K [1 ]
JAKOBS, KH [1 ]
机构
[1] UNIV MUNICH,MED KLIN 1,D-8000 MUNICH 70,FED REP GER
来源
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1989年 / 172卷 / 03期
关键词
D O I
10.1016/0922-4106(89)90051-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:211 / 221
页数:11
相关论文
共 37 条
[11]   ASSESSMENT OF THE BETA-ADRENERGIC-RECEPTOR PATHWAY IN THE INTACT FAILING HUMAN-HEART - PROGRESSIVE RECEPTOR DOWN-REGULATION AND SUBSENSITIVITY TO AGONIST RESPONSE [J].
FOWLER, MB ;
LASER, JA ;
HOPKINS, GL ;
MINOBE, W ;
BRISTOW, MR .
CIRCULATION, 1986, 74 (06) :1290-1302
[12]  
GARRITY M, 1983, J BIOL CHEM, V258, P8692
[13]   PURIFICATION AND IMMUNOCHEMICAL CHARACTERIZATION OF THE MAJOR PERTUSSIS-TOXIN-SENSITIVE GUANINE-NUCLEOTIDE-BINDING PROTEIN OF BOVINE-NEUTROPHIL MEMBRANES [J].
GIERSCHIK, P ;
SIDIROPOULOS, D ;
SPIEGEL, A ;
JAKOBS, KH .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1987, 165 (01) :185-194
[14]   ANTIBODIES AGAINST A RETINAL GUANINE NUCLEOTIDE-BINDING PROTEIN CROSS-REACT WITH A SINGLE PLASMA-MEMBRANE PROTEIN IN NON-RETINAL TISSUES [J].
GIERSCHIK, P ;
SIMONS, C ;
WOODARD, C ;
SOMERS, R ;
SPIEGEL, A .
FEBS LETTERS, 1984, 172 (02) :321-325
[15]   ANTISERA AGAINST A GUANINE-NUCLEOTIDE BINDING-PROTEIN FROM RETINA CROSS-REACT WITH THE BETA-SUBUNIT OF THE ADENYLYL CYCLASE-ASSOCIATED GUANINE-NUCLEOTIDE BINDING-PROTEINS, NS AND NI [J].
GIERSCHIK, P ;
CODINA, J ;
SIMONS, C ;
BIRNBAUMER, L ;
SPIEGEL, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (03) :727-731
[16]   G-PROTEINS - TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS [J].
GILMAN, AG .
ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :615-649
[17]  
GOLDSMITH P, 1987, J BIOL CHEM, V262, P14683
[18]  
JAKOBS KH, 1976, J CYCLIC NUCL PROT, V2, P381
[19]  
Johnson R A, 1979, Adv Cyclic Nucleotide Res, V10, P135
[20]  
JONES SB, 1988, J BIOL CHEM, V263, P14236