TOTAL SYNTHESIS OF THE ETHANOL-INDUCIBLE, PROINFLAMMATORY AUTACOID 3(S)-HYDROXY-LEUKOTRIENE B-4 (3-OH-LTB(4)) AND ANALOGS

被引：15

作者：

CHAUHAN, K

BHATT, RK

FALCK, JR

CAPDEVILA, JH

机构：

[1] UNIV TEXAS, SW MED CTR, DEPT MOLEC GENET, DALLAS, TX 75235 USA

[2] UNIV TEXAS, SW MED CTR, DEPT PHARMACOL, DALLAS, TX 75235 USA

[3] VANDERBILT UNIV, SCH MED, DEPT MED, NASHVILLE, TN 37205 USA

[4] VANDERBILT UNIV, SCH MED, DEPT BIOCHEM, NASHVILLE, TN 37205 USA

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 12期

关键词：

EICOSANOID; CHELATION-CONTROLLED REDUCTION; RIEKE ZINC; WITTIG;

D O I：

10.1016/S0040-4039(00)73170-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3(S)-Hydroxy-Leukotriene B-4 (1a), its 3(R)-epimer 1b, and a 14,15-acetylenic analogue were efficiently prepared via chelation-controlled reduction of ketone 12, obtained by acetylide addition to chiral beta-hydroxylactones 7/9.

引用

页码：1825 / 1828

页数：4

共 17 条

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