STEREOSELECTIVE EFFECT OF PHENPROCOUMON ENANTIOMERS ON THE BINDING OF BENZODIAZEPINES TO HUMAN SERUM-ALBUMIN

被引：15

作者：

FITOS, I

SIMONYI, M

机构：

[1] Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest

来源：

CHIRALITY | 1992年 / 4卷 / 01期

关键词：

PROTEIN BINDING; AFFINITY CHROMATOGRAPHY; RESOLUTION; ALLOSTERIC INTERACTION; INCREASED ENANTIOSELECTIVITY;

D O I：

10.1002/chir.530040106

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of phenprocoumon enantiomers on the stereoselective binding of 3-substituted 1,4-benzodiazepines to human serum albumin (HSA) was studied by chromatography on HSA-Sepharose column. (S)-Phenprocoumon exerts stereoselective allosteric interaction on the binding of benzodiazepines. The structural requirements of enhanced stereoselectivities are similar to those found previously with (S)-warfarin.

引用

页码：21 / 23

页数：3

共 10 条

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