MONITORING THE ACTIVITY OF ANTIVIRAL THERAPY FOR HIV-INFECTION USING A POLYMERASE CHAIN-REACTION METHOD COUPLED WITH REVERSE TRANSCRIPTION

被引：20

作者：

KOJIMA, E

SHIRASAKA, T

ANDERSON, B

CHOKEKIJCHAI, S

SEI, S

YARCHOAN, R

MITSUYA, H

机构：

[1] NCI,MED BRANCH,EXPTL RETROVIROL SECT,BETHESDA,MD 20892

[2] NCI,MED BRANCH,RETROVIRAL DIS SECT,BETHESDA,MD 20892

[3] NCI,PEDIAT BRANCH,INFECT DIS SECT,BETHESDA,MD 20892

来源：

AIDS | 1993年 / 7卷

关键词：

HIV-1; VIRAL LOAD; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; DRUG RESISTANCE; POL GENE MUTATION;

D O I：

10.1097/00002030-199311002-00019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aim: To monitor the anti-HIV-1 activity of antiretroviral agents in patients with HIV-1 infection. Method: Quantification of viral RNA copy in plasma or serum using a polymerase chain reaction method coupled with reverse transcription. Conclusions: The HIV-1 RNA copy number represents the HIV-1 viremia status in patients with HIV-1 infection. This copy number is likely to be useful in monitoring the effectiveness of antiviral therapy and the method is likely to be built into every clinical trial of anti-HIV-1 therapy in the near future.

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收藏

页码：S101 / S105

页数：5

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