A NEW SHORT AND EFFICIENT STRATEGY FOR THE SYNTHESIS OF QUINOLONE ANTIBIOTICS

被引：159

作者：

JACKSON, A ^{[1
]}

METHCOHN, O ^{[1
]}

机构：

[1] UNIV SUNDERLAND,DEPT CHEM,SUNDERLAND SR1 3SD,DURHAM,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 13期

关键词：

D O I：

10.1039/c39950001319

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple protocol for the synthesis of quinolone antibiotics is exemplified for the synthesis of norfloxacin; 3-chloro-4-fluoroaniline with triethyl orthoformate is transformed into its N-ethyl-N-formyl derivative which reacts with methyl malonyl morpholide and phosphoryl chloride at 100 degrees C to give 6-fluoro-7-chloro-1 -ethylquinol-4-one-3-carboxylic acid, which has previously been converted into norfloxacin by the action of piperazine.

引用

页码：1319 / 1319

页数：1