COMPARISON OF BRONCHODILATOR RESPONSES TO ADRENOMEDULLIN AND PROADRENOMEDULLIN N-TERMINAL-20-PEPTIDE

被引：14

作者：

KANAZAWA, H

KAWAGUCHI, T

FUJII, T

KUDOH, S

HIRATA, K

KURIHARA, N

TAKEDA, T

机构：

[1] The First Department, Internal Medicine Osaka City University Medical School 1-5-7, 545, Asahi-machi, Abenoku Osaka

来源：

LIFE SCIENCES | 1995年 / 57卷 / 16期

关键词：

ADRENOMEDULLIN; PROADRENOMEDULLIN N-TERMINAL 20 PEPTIDE; BRONCHODILATION;

D O I：

10.1016/0024-3205(95)02117-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This study was designed to determine and compare airway responses to synthetic human adrenomedullin(AM) and proadrenomedullin N-terminal 20 peptide (PAMP) in anesthetized guinea pigs in vivo. 10(-7) M AM and PAMP significantly inhibited acetylcholine-and histamine-induced bronchoconstriction. However, this significant bronchodilator effect of PAMP lasted about five minutes, which was much shorter than that of AM. In addition, the bronchodilator effect of AM is approximately 100-fold more potent than PAMP. We demonstrated that PAMP had a potent bronchodilator activity, and induced a rapid and short-lasting bronchodilation. These findings suggest that AM and PAMP may play important roles in airway functions.

引用

页码：PL241 / PL245

页数：5

共 9 条

[1] AIRWAY NEUTRAL ENDOPEPTIDASE-LIKE ENZYME MODULATES TACHYKININ-INDUCED BRONCHOCONSTRICTION INVIVO [J].

DUSSER, DJ ;

UMENO, E ;

GRAF, PD ;

DJOKIC, T ;

BORSON, DB ;

NADEL, JA .

JOURNAL OF APPLIED PHYSIOLOGY, 1988, 65 (06) :2585-2591

[2] SPECIFIC RECEPTORS FOR ADRENOMEDULLIN IN CULTURED RAT VASCULAR SMOOTH-MUSCLE CELLS [J].

EGUCHI, S ;

HIRATA, Y ;

KANO, H ;

SATO, K ;

WATANABE, Y ;

WATANABE, TX ;

NAKAJIMA, K ;

SAKAKIBARA, S ;

MARUMO, F .

FEBS LETTERS, 1994, 340 (03) :226-230

[3] DISTRIBUTION AND CHARACTERIZATION OF IMMUNOREACTIVE ADRENOMEDULLIN IN HUMAN TISSUE AND PLASMA [J].

ICHIKI, Y ;

KITAMURA, K ;

KANGAWA, K ;

KAWAMOTO, M ;

MATSUO, H ;

ETO, T .

FEBS LETTERS, 1994, 338 (01) :6-10

[4] ADRENOMEDULLIN, A NEWLY DISCOVERED HYPOTENSIVE PEPTIDE, IS A POTENT BRONCHODILATOR [J].

KANAZAWA, H ;

KURIHARA, N ;

HIRATA, K ;

KUDOH, S ;

KAWAGUCHI, T ;

TAKEDA, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 205 (01) :251-254

[5] COMPLETE AMINO-ACID-SEQUENCE OF PORCINE ADRENOMEDULLIN AND CLONING OF CDNA-ENCODING ITS PRECURSOR [J].

KITAMURA, K ;

KANGAWA, K ;

KOJIMA, M ;

ICHIKI, Y ;

MATSUO, H ;

ETO, T .

FEBS LETTERS, 1994, 338 (03) :306-310

[6] IDENTIFICATION AND HYPOTENSIVE ACTIVITY OF PROADRENOMEDULLIN N-TERMINAL-20 PEPTIDE (PAMP) [J].

KITAMURA, K ;

KANGAWA, K ;

ISHIYAMA, Y ;

WASHIMINE, H ;

ICHIKI, Y ;

KAWAMOTO, M ;

MINAMINO, N ;

MATSUO, H ;

ETO, T .

FEBS LETTERS, 1994, 351 (01) :35-37

[7] ADRENOMEDULLIN - A NOVEL HYPOTENSIVE PEPTIDE ISOLATED FROM HUMAN PHEOCHROMOCYTOMA [J].

KITAMURA, K ;

KANGAWA, K ;

KAWAMOTO, M ;

ICHIKI, Y ;

NAKAMURA, S ;

MATSUO, H ;

ETO, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 192 (02) :553-560

[8] PRODEPIN - A NEW PRODUCT OF THE ADRENOMEDULLIN (ADM) GENE HAS SYSTEMIC VASODILATOR ACTIVITY [J].

LIPPTON, H ;

GAO, YQ ;

LIN, B ;

HEATON, J ;

FERRARA, J ;

DEVITO, M ;

GRANGER, T ;

PIGOTT, J ;

CHANG, JK ;

HYMAN, A .

LIFE SCIENCES, 1994, 54 (23) :PL409-PL412

[9] IMMUNOREACTIVE PROADRENOMEDULLIN N-TERMINAL-20 PEPTIDE IN HUMAN TISSUE, PLASMA AND URINE [J].

WASHIMINE, H ;

KITAMURA, K ;

ICHIKI, Y ;

YAMAMOTO, Y ;

KANGAWA, K ;

MATSUO, H ;

ETO, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 202 (02) :1081-1087

← 1 →