PRODEPIN - A NEW PRODUCT OF THE ADRENOMEDULLIN (ADM) GENE HAS SYSTEMIC VASODILATOR ACTIVITY

被引：13

作者：

LIPPTON, H

GAO, YQ

LIN, B

HEATON, J

FERRARA, J

DEVITO, M

GRANGER, T

PIGOTT, J

CHANG, JK

HYMAN, A

机构：

[1] LOUISIANA STATE UNIV, SCH MED, DEPT PHARMACOL, NEW ORLEANS, LA 70112 USA

[2] TULANE MED SCH, DEPT SURG, CARDIOPULM LAB, NEW ORLEANS, LA 70112 USA

[3] LOUISIANA STATE UNIV, SCH MED, DEPT ANESTHESIOL, NEW ORLEANS, LA 70112 USA

[4] PENINSULA LABS, BELMONT, CA USA

[5] TULANE MED SCH, DEPT PHARMACOL, NEW ORLEANS, LA 70112 USA

[6] TULANE MED SCH, DEPT INTERNAL MED, NEW ORLEANS, LA 70112 USA

来源：

LIFE SCIENCES | 1994年 / 54卷 / 23期

基金：

美国国家卫生研究院;

关键词：

PRODEPIN; ADRENOMEDULLIN GENE; SYSTEMIC VASODILATOR ACTIVITY;

D O I：

10.1016/0024-3205(94)90124-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The purpose of the present study was to investigate the effects of products of the ADM gene other than ADM on systemic hemodynamics in the anesthetized rat, rabbit, piglet, cat and dog. Bolus intravenous (i.v.) injections of rat proADM(22-41) (3-30 mu g) significantly decreased systemic arterial pressure (SAP) and systemic vascular resistance in the anesthetized rat. Unlike ADM, rat proADM(22-41) markedly increased cardiac output in the rat. Bolus i.v. injections of human proADM(22-41) up to 500 mu g had not effect in all species studied and rat proADM(22-41) had no effect in species other than the rat. The present data suggest that rat proADM(22-41) is a novel product of the ADM gene other than ADM and possesses marked systemic vasodilator activity. The present data also suggest that the hemodynamic activity of this peptide is species specific.

引用

页码：PL409 / PL412

页数：4

共 6 条

[1] HEMODYNAMIC-EFFECTS OF A NOVEL HYPOTENSIVE PEPTIDE, HUMAN ADRENOMEDULLIN, IN RATS [J].