ANALOGS OF THE ANTIBIOTIC PUROMYCIN AS POTENTIAL PRODRUGS OF 3'-AMINO-3'-DEOXYTHYMIDINE

被引：9

作者：

WENGEL, J ^{[1
]}

MOTAWIA, MS ^{[1
]}

PEDERSEN, EB ^{[1
]}

NIELSEN, CM ^{[1
]}

机构：

[1] STATENS SERUMINST,DEPT ENTEROVIRUS,RETROVIRUS LAB,DK-2300 COPENHAGEN,DENMARK

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1992年 / 29卷 / 01期

关键词：

D O I：

10.1002/jhet.5570290102

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Condensation of L- and D-3'-amino-2',3'-dideoxynucleosides 2-5 with N-BOC-protected aminoacids 6 and 13 using dicyclohexylcarbodiimide and N-hydroxysuccinimide in DMF is reported to give the N-BOC-protected acylamino aminonucleosides 7-9 and 14 in 51-81% yield. After deprotection using trifluoroacetic acid the corresponding unprotected new analogues of puromucin 10-12 and 15 were obtained in 43-56% yield. These compounds did not show any significant antiviral activity using HIV (stain HTLV-III B)-infected MT-4 cells as target system.

引用

页码：5 / 9

页数：5

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