INHIBITION OF SPONTANEOUS TESTICULAR LEYDIG-CELL TUMOR-DEVELOPMENT IN F344 RATS BY DEHYDROEPIANDROSTERONE

被引：21

作者：

RAO, MS

SUBBARAO, V

YELDANDI, AV

REDDY, JK

机构：

[1] Department of Pathology, Northwestern University Medical School, Chicago, IL 60611-3008

来源：

CANCER LETTERS | 1992年 / 65卷 / 02期

关键词：

TESTIS; ANTICARCINOGEN; STEROIDS;

D O I：

10.1016/0304-3835(92)90155-O

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The incidence of spontaneous Leydig cell tumors of testis is very high in old F-344 rats. We have examined the effect of dehydroepiandrosterone (DHEA), a steroid hormone with antimitotic and anticarcinogenic properties, on spontaneous Leydig cell tumorigenesis. Fifteen-week-old male F-344 rats were fed a diet containing DHEA (0.45% w/w) for 84 weeks. At the termination of experiment none of the 13 rats had Leydig cell hyperplasia or Leydig cell tumors. All the eight control rats of comparable age had Leydig cell tumors. These findings suggest that DHEA is a potent inhibitor of spontaneous Leydig cell tumors of testis in aged rats.

引用

页码：123 / 126

页数：4

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