P53 PROTEIN, PCNA STAINING, AND DNA CONTENT IN FOLLICULAR NEOPLASMS OF THE THYROID-GLAND

被引:24
作者
CZYZ, W
JOENSUU, H
PYLKKANEN, L
KLEMI, PJ
机构
[1] UNIV TURKU,CENT HOSP,DEPT PATHOL,SF-20520 TURKU,FINLAND
[2] MED UNIV LODZ,ENDOCRINOL SURG CLIN,LODZ,POLAND
[3] UNIV TURKU,CENT HOSP,DEPT RADIOTHERAPY & ONCOL,TURKU,FINLAND
关键词
FOLLICULAR NEOPLASMS; THYROID GLAND; P53; PROTEIN; PCNA; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY;
D O I
10.1002/path.1711740406
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Forty-nine follicular adenomas and II follicular carcinomas of the thyroid were investigated by immunohistochemistry for the expression of p53 protein and proliferating cell nuclear antigen (PCNA). The DNA ploidy and the S-phase fraction (SPF) of the neoplasms were analysed by flow cytometry. Twelve adenomas (24 per cent) and six carcinomas (55 per cent) were DNA non-diploid (P=0.07). The carcinomas had a higher proliferation rate than the adenomas when assessed either by SPF size (median 9.9 per cent vs. 2.9 per cent, P=0.0003) or by PCNA staining intensity (P<0.0001). Some scattered nuclei in two (4 per cent) adenomas and in three (27 per cent) carcinomas stained positively for p53 (P=0.04). The two adenomas with positive staining for p53 were subserially sectioned, but no signs of invasion were found; both patients are alive and well 6 and 7 years after surgery. One of the two adenomas showing positive p53 nuclear staining was DNA aneuploid, and both were positive in PCNA staining, but their SPFs were low (2.1 and 3.3 per cent). We conclude that p53 protein expression is not confined to follicular carcinomas; scattered p53-positive cells may also be present in histologically and clinically benign follicular adenomas. Because both follicular adenomas and carcinomas may be DNA aneuploid and their SPF and PCNA staining distributions overlap, the distinction between follicular adenoma and carcinoma should still be based on histological criteria.
引用
收藏
页码:267 / 274
页数:8
相关论文
共 32 条
  • [21] NEGATIVE GROWTH-REGULATION IN A GLIOBLASTOMA TUMOR-CELL LINE THAT CONDITIONALLY EXPRESSES HUMAN WILD-TYPE P53
    MERCER, WE
    SHIELDS, MT
    AMIN, M
    SAUVE, GJ
    APPELLA, E
    ROMANO, JW
    ULLRICH, SJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (16) : 6166 - 6170
  • [22] P53-GENE MUTATIONS ASSOCIATED WITH ANAPLASTIC TRANSFORMATION OF HUMAN THYROID CARCINOMAS
    NAKAMURA, T
    YANA, I
    KOBAYASHI, T
    SHIN, E
    KARAKAWA, K
    FUJITA, S
    MIYA, A
    MORI, T
    NISHISHO, I
    TAKAI, S
    [J]. JAPANESE JOURNAL OF CANCER RESEARCH, 1992, 83 (12): : 1293 - 1298
  • [23] NUORVA K, 1993, AM J PATHOL, V142, P725
  • [24] P53 CELLULAR TUMOR-ANTIGEN - ANALYSIS OF MESSENGER-RNA LEVELS IN NORMAL ADULT TISSUES, EMBRYOS, AND TUMORS
    ROGEL, A
    POPLIKER, M
    WEBB, CG
    OREN, M
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1985, 5 (10) : 2851 - 2855
  • [25] RUGGE M, 1992, CANCER EPIDEM BIOMAR, V1, P551
  • [26] SHIMIZU T, 1993, CANCER-AM CANCER SOC, V71, P2807, DOI 10.1002/1097-0142(19930501)71:9<2807::AID-CNCR2820710920>3.0.CO
  • [27] 2-5
  • [28] SPRENGER E, 1977, ACTA CYTOL, V21, P528
  • [29] EXPRESSION OF P53 IN COLORECTAL-CANCER AND DYSPLASIA COMPLICATING ULCERATIVE-COLITIS
    TAYLOR, HW
    BOYLE, M
    SMITH, SC
    BUSTIN, S
    WILLIAMS, NS
    [J]. BRITISH JOURNAL OF SURGERY, 1993, 80 (04) : 442 - 444
  • [30] A DETERGENT-TRYPSIN METHOD FOR THE PREPARATION OF NUCLEI FOR FLOW CYTOMETRIC DNA ANALYSIS
    VINDELOV, LL
    CHRISTENSEN, IJ
    NISSEN, NI
    [J]. CYTOMETRY, 1983, 3 (05): : 323 - 327