RECENT CONTRIBUTIONS OF CARBONYLATION REACTION TO THE SYNTHESIS OF FLUORINATED PHARMACEUTICAL COMPOUNDS

被引：14

作者：

BOTTEGHI, C

DELPONTE, G

MARCHETTI, M

PAGANELLI, S

机构：

[1] FAC CIENCIAS FARMACEUT RIBEIRAO PRETO,DEPT CIENCIAS FARMACEUT,BR-14049 RIBEIRAO PRET,SP,BRAZIL

[2] CNR,IST APPLICAZ TECN CHIM AVANZATE PROBLEMI AGROBIOL,I-07100 SASSARI,ITALY

来源：

JOURNAL OF MOLECULAR CATALYSIS | 1994年 / 93卷 / 01期

关键词：

CARBONYLATION; FLUORINATION; ORGANOFLUORINE COMPOUNDS; PHARMACEUTICALS;

D O I：

10.1016/0304-5102(94)00077-8

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Several organofluorine compounds endowed with unique pharmaceutical activity, such as fluorinated aminoacids, fluorinated artylpropanoic acids, etc. can be conveniently prepared by hydroformylation, hydrocarboxylation and hydroesterification of appropriated olefins containing one or more fluorine atoms in definite positions of the molecule. Many organic-fluorinated compounds obtained by carbonylation procedures represent very useful intermediates for the synthesis of pharmacologically active molecules, as for instance: fluor-indoles, fluor beta-lactams and fluor uracils.

引用

页码：1 / 21

页数：21

共 59 条

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