NEUTROPHIL CHEMOTAXIS IN RHEUMATOID-ARTHRITIS - EFFECT OF D-PENICILLAMINE, GOLD SALTS, AND LEVAMISOLE

The effect of therapeutic concentrations of D-penicillamine, sodium aurothiomalate, and levamisole on in vitro neutrophil chemotaxis and random migration in normal subjects and patients with rheumatoid arthritis was studied. D-penicillamine produced no changes. Sodium aurothiomalate produced dose-related reductions in chemotaxis in normal subjects and in patients who had a good clinical response to gold therapy, while patients who had failed to respond to gold showed a minimal, non-dose-dependent reduction. Levamisole produced dose-dependent stimulation of chemotaxis, a greater effect being found with the patients' cells. Neutrophil chemotaxis improved to normal values in most patients responding to several months of D-penicillamine treatment but showed an immediate and marked stimulation in patients treated with levamisole.