CIRCADIAN PATTERN OF LARGE NEUTRAL AMINO-ACIDS, GLUCOSE, INSULIN, AND FOOD-INTAKE IN ANOREXIA-NERVOSA AND BULIMIA-NERVOSA

被引：26

作者：

SCHREIBER, W ^{[1
]}

SCHWEIGER, U ^{[1
]}

WERNER, D ^{[1
]}

BRUNNER, G ^{[1
]}

TUSCHL, RJ ^{[1
]}

LAESSLE, RG ^{[1
]}

KRIEG, JC ^{[1
]}

FICHTER, MM ^{[1
]}

PIRKE, KM ^{[1
]}

机构：

[1] ROSENECK HOSP BEHAV MED,PRIEN AM CHIEMSEE,GERMANY

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1991年 / 40卷 / 05期

关键词：

D O I：

10.1016/0026-0495(91)90231-K

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin, glucose, and large neutral amino acids (LNAA) were studied in 10 patients with anorexia nervosa, 13 patients with bulimia nervosa, and 15 healthy controls. Blood samples were collected at hourly intervals during the day and at two-hour intervals during the night over a 24-hour period. Ad libitum caloric and relative carbohydrate intake was significantly reduced in the anorectic and bulimic patients. Elevated concentrations of β-hydroxybutyric acid (BHBA) were seen in the bulimic group, and low triiodothyronine (T3) concentrations in the anorectic group. Mean plasma glucose and insulin concentrations were significantly lowered in both groups. The tryptophan (Trp) to LNAA ratio was reduced in anorectic, but not in bulimic patients. These findings suggest that Trp influx into the brain is reduced in anorectic patients, possibly impairing central serotonergic function. © 1991.

引用

页码：503 / 507

页数：5

共 22 条

[11] THE GONADOTROPIC FUNCTION OF INSULIN [J].