EXPERIMENTAL SYPHILIS IN THE RABBIT - PASSIVE TRANSFER OF IMMUNITY WITH IMMUNOGLOBULIN-G FROM IMMUNE SERUM

被引：38

作者：

TITUS, RG ^{[1
]}

WEISER, RS ^{[1
]}

机构：

[1] UNIV WASHINGTON, SCH MED, DEPT MICROBIOL & IMMUNOL, SEATTLE, WA 98195 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1979年 / 140卷 / 06期

关键词：

D O I：

10.1093/infdis/140.6.904

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A preparation of immunoglobulin G isolated from a pool of immune sera derived from rabbits with long-term syphilis was shown to possess a high degree of purity as judged by immunodiffusion and protein electrophoresis. The antitreponemal power of the preparation of immunoglobulin G and that of the immune serum pool from which it was derived were found to be equivalent in both the skin protection and the systemic protection test. The observation that neither normal serum nor a pool of serum derived from animals “immunized” with Salmonella typhi, Escherichia coli, Streptococcus pyogenes, or zymosan was protective indicates that the protective power of the immune serum studied was due to specific antibodies residing principally, if not entirely, in the immunoglobulin G fraction of the serum. © 1979 by The University of Chicago.

引用

页码：904 / 913

页数：10

共 42 条

[11] Immunity studies in experimental syphilis - Spirocheticidal properties of serums in latent and experimental syphilis with some observations on immunity
Eberson, F
[J]. ARCHIVES OF DERMATOLOGY AND SYPHILOLOGY, 1921, 4 (04): : 490 - 511
[12] FRUHMAN GJ, 1972, P SOC EXP BIOL MED, V141, P101
[13] Kabat E. A., 1961, EXPT IMMUNOCHEMISTRY
[14] CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4
LAEMMLI, UK
[J]. NATURE, 1970, 227 (5259) : 680 - +
[15] MAGNUSON HAROLD J., 1948, AMER JOUR SYPHILIS GONORRHEA AND VENEREAL DIS, V32, P418
[16] MAGNUSON HAROLD J., 1949, AMER JOUR SYPHILIS GONORRHEA AND VENEREAL DIS, V33, P297
[17] MAGNUSON HJ, 1951, J IMMUNOL, V67, P41
[18] MCLEOD C P, 1953, Am J Syph Gonorrhea Vener Dis, V37, P9
[19] METZGER M, 1969, BRIT J VENER DIS, V45, P308
[20] MILLER JN, 1973, J IMMUNOL, V110, P1206

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