INCREASED COEXPRESSION OF CFTR AND S100 CALCIUM-BINDING PROTEINS MRP8 AND MRP14 MESSENGER-RNAS IN CYSTIC-FIBROSIS HUMAN TRACHEAL GLAND-CELLS

被引：42

作者：

RENAUD, W

MERTEN, M

FIGARELLA, C

机构：

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 201卷 / 03期

关键词：

D O I：

10.1006/bbrc.1994.1876

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have demonstrated for the first time, by Northern analysis, the presence of the S-100 calcium binding proteins MRP8 (also called ''cystic fibrosis protein') and MRP14 mRNAs in cultured human tracheal gland cells, obtained from normal and cystic fibrosis (CF) patients. A significant increase of these mRNAs in cells of CF origin (as well as that of CFTR mRNA) is shown. These results allow us to assume a potential pretranslational regulation of MRP8 and MRP14 gene expression related to the presence of a mutated CFTR gene. (C) 1994 Academic Press, Inc.

引用

页码：1518 / 1525

页数：8

共 40 条

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