SIMPLE TANDEM REPEAT DNA POLYMORPHISM IN THE HUMAN GLYCOGEN-SYNTHASE GENE IS ASSOCIATED WITH NIDDM IN JAPANESE SUBJECTS

被引：33

作者：

KUROYAMA, H ^{[1
]}

SANKE, T ^{[1
]}

OHAGI, S ^{[1
]}

FURUTA, M ^{[1
]}

FURUTA, H ^{[1
]}

NANJO, K ^{[1
]}

机构：

[1] WAKAYAMA UNIV MED SCI,DEPT MED 1,WAKAYAMA 640,JAPAN

来源：

DIABETOLOGIA | 1994年 / 37卷 / 05期

关键词：

NIDDM; GLYCOGEN SYNTHASE; DNA POLYMORPHISM; GENETICS; HYPERTENSION;

D O I：

10.1007/s001250050144

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the possible association between alleles of a simple tandem repeat DNA polymorphism in the human glycogen synthase gene and non-obese non-insulin-dependent diabetes (NIDDM) in Japanese subjects. Nine alleles (-4G, -3G, -2G, -1G, 0G, 1G, 2G, 3G, and 4G) were identified in the study group of 164 patients with NIDDM and 115 nondiabetic subjects. The overall frequency distribution of the glycogen synthase gene alleles was significantly different between the two groups (p = 0.0316). The 2G allele was found more frequently in patients with NIDDM than in non-diabetic subjects (17.7 % vs 8.7 %, p = 0.0016). These results suggest that the 2G allele could be a genetic marker of NIDDM in Japanese subjects.

引用

页码：536 / 539

页数：4

共 10 条

[1] ASSOCIATION BETWEEN POLYMORPHISM OF THE GLYCOGEN-SYNTHASE GENE AND NON-INSULIN-DEPENDENT DIABETES-MELLITUS
GROOP, LC
KANKURI, M
SCHALINJANTTI, C
EKSTRAND, A
NIKULAIJAS, P
WIDEN, E
KUISMANEN, E
ERIKSSON, J
FRANSSILAKALLUNKI, A
SALORANTA, C
KOSKIMIES, S
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1993, 328 (01) : 10 - 14
[2] KADOWAKI T, 1993, NEW ENGL J MED, V328, P1568
[3] PERMUTT MA, 1991, GENETICS DIABETES, V2, P495
[4] IMPAIRED ACTIVATION OF GLYCOGEN-SYNTHASE IN PEOPLE AT INCREASED RISK FOR DEVELOPING NIDDM
SCHALINJANTTI, C
HARKONEN, M
GROOP, LC
[J]. DIABETES, 1992, 41 (05) : 598 - 604
[5] MULTIPLE DEFECTS IN MUSCLE GLYCOGEN-SYNTHASE ACTIVITY CONTRIBUTE TO REDUCED GLYCOGEN-SYNTHESIS IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS
THORBURN, AW
GUMBINER, B
BULACAN, F
BRECHTEL, G
HENRY, RR
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (02) : 489 - 495
[6] DECREASED INSULIN ACTIVATION OF GLYCOGEN-SYNTHASE IN SKELETAL-MUSCLES IN YOUNG NONOBESE CAUCASIAN 1ST-DEGREE RELATIVES OF PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS
VAAG, A
HENRIKSEN, JE
BECKNIELSEN, H
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1992, 89 (03) : 782 - 788
[7] IMPAIRED EXPRESSION OF GLYCOGEN-SYNTHASE MESSENGER-RNA IN SKELETAL-MUSCLE OF NIDDM PATIENTS
VESTERGAARD, H
BJORBAEK, C
ANDERSEN, PH
BAK, JF
PEDERSEN, O
[J]. DIABETES, 1991, 40 (12) : 1740 - 1745
[8] GLYCOGEN-SYNTHASE AND PHOSPHOFRUCTOKINASE PROTEIN AND MESSENGER-RNA LEVELS IN SKELETAL-MUSCLE FROM INSULIN-RESISTANT PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS
VESTERGAARD, H
LUND, S
LARSEN, FS
BJERRUM, OJ
PEDERSEN, O
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (06) : 2342 - 2350
[9] IDENTIFICATION OF A SIMPLE TANDEM REPEAT DNA POLYMORPHISM IN THE HUMAN GLYCOGEN-SYNTHASE GENE AND LINKAGE TO 5 MARKERS ON CHROMOSOME-19Q
VIONNET, N
BELL, GI
[J]. DIABETES, 1993, 42 (06) : 930 - 932
[10] ZOUALI H, 1993, NEW ENGL J MED, V328, P1568

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