COMPARATIVE-STUDY OF BONE-MARROW INDUCED BY PURIFIED BMP AND RECOMBINANT HUMAN BMP-2

被引：32

作者：

KUSUMOTO, K ^{[1
]}

BESSHO, K ^{[1
]}

FUJIMURA, K ^{[1
]}

KONISHI, Y ^{[1
]}

OGAWA, Y ^{[1
]}

IIZUKA, T ^{[1
]}

机构：

[1] KYOTO UNIV,FAC MED,DEPT ORAL & MAXILLOFACIAL SURG,SAKYO KU,KYOTO 606,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 215卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.2454

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Into a calf muscle pouch in Wistar rats, 50 mu g purified bone morphogenetic protein (pBMP) or 50 mu g recombinant human bone morphogenetic protein-2 (rhBMP-2) was implanted using atelopeptide type I collagen solution (CL) as a carrier. Three weeks later bone and bone marrow were induced in both groups. These induced,bone and bone marrow were studied histologically. In the pBMP+CL group (n=5), rich bone matrix and little bone marrow were observed. There was no fatty marrow or angioid tissue observed. In the rhBMP-2+CL group (n=5), bone matrix and rich marrow including fatty marrow and angioid tissue were observed around and among the bony trabeculae. It was suggested that a ''self-supporting bone organ'' was induced. (C) 1995 Academic Press, Inc.

引用

页码：205 / 211

页数：7

共 19 条

[1] STUDIES ON A FACTOR RESPONSIBLE FOR NEW BONE-FORMATION FROM OSTEOSARCOMA IN MICE [J].

AMITANI, K ;

NAKATA, Y .

CALCIFIED TISSUE RESEARCH, 1975, 17 (02) :139-150

[2] PURIFICATION OF BONE MORPHOGENETIC PROTEIN DERIVED FROM BOVINE BONE-MATRIX [J].

BESSHO, K ;

TAGAWA, T ;

MURATA, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (02) :595-601

[3]

BESSHO K, 1990, Mie Medical Journal, V40, P61

[4] BONE MORPHOGENETIC PROTEIN EXPRESSION IN HUMAN ATHEROSCLEROTIC LESIONS [J].

BOSTROM, K ;

WATSON, KE ;

HORN, S ;

WORTHAM, C ;

HERMAN, IM ;

DEMER, LL .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (04) :1800-1809

[5] LOCAL BONE-GROWTH FACTORS [J].

CANALIS, E .

CALCIFIED TISSUE INTERNATIONAL, 1984, 36 (06) :632-634

[6] EXPERIMENTAL STUDIES ON BONE-INDUCING ACTIVITY OF COMPOSITES OF ATELOPEPTIDE TYPE-I COLLAGEN AS A CARRIER FOR ECTOPIC OSTEOINDUCTION BY RHBMP-2 [J].

FUJIMURA, K ;

BESSHO, K ;

KUSUMOTO, K ;

OGAWA, Y ;

IIZUKA, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 208 (01) :316-322

[7]

GAO TJ, 1993, ANN CHIR GYNAECOL, V82, P77

[8]

HAUSCHKA PV, 1986, J BIOL CHEM, V261, P2665

[9] HISTOLOGICAL-CHANGES OF IMPLANTED COLLAGEN MATERIAL DURING BONE INDUCTION [J].

HORISAKA, Y ;

OKAMOTO, Y ;

MATSUMOTO, N ;

YOSHIMURA, Y ;

HIRANO, A ;

NISHIDA, M ;

KAWADA, J ;

YAMASHITA, K ;

TAKAGI, T .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1994, 28 (01) :97-103

[10] PATHOLOGICAL AND ENZYME HISTOCHEMICAL-STUDIES ON BONE-FORMATION INDUCED BY BONE MORPHOGENETIC PROTEIN IN MOUSE MUSCLE-TISSUE [J].

KAMEGAI, A ;

TANABE, T ;

NAGAHARA, K ;

KUMASA, S ;

MORI, M .

ACTA HISTOCHEMICA, 1990, 89 (01) :25-35

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