PRODUCTS OF LIPID-PEROXIDATION AND CHANGES IN SULFHYDRYL COMPOUNDS IN PANCREATIC TISSUE OF RATS WITH CERULEIN-INDUCED ACUTE-PANCREATITIS

被引：7

作者：

DABROWSKI, A ^{[1
]}

GABRYELEWICZ, A ^{[1
]}

CHWIECKO, M ^{[1
]}

机构：

[1] MED ACAD BIALYSTOK,DEPT INORGAN & ANALYT CHEM,PL-15276 BIALYSTOK,POLAND

来源：

BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY | 1991年 / 46卷 / 01期

关键词：

D O I：

10.1016/0885-4505(91)90045-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acute edematous pancreatitis was induced in rats by iv infusion of caerulein (CR) in a supramaximal dose of 7.5 × 10-6g × kg-1 × hr-1 during 6 hr. The most important finding of our study was the marked decrease of protein and nonprotein thiol content in pancreatic tissue of rats with CR-induced acute pancreatitis (AP). Oxygen radicals as well as 4-hydroxyalkenals resulting from lipid peroxidation are believed to be at least partly responsible for this phenomenon. Covalent binding of excessive amounts of 4-hydroxyalkenals to pancreatic tissue protein sulfhydryl groups has been documented. Presented data suggest a serious disturbance of sulfhydryl compounds metabolism in pancreatic tissue of rats with CR-induced AP which may be of importance in the pathogenesis of the disease. © 1991.

引用

页码：10 / 16

页数：7

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