THE NONPEPTIDE NK-2 ANTAGONIST SR 48968 IS ALSO A NK-3 ANTAGONIST IN THE GUINEA-PIG BUT NOT IN THE RAT

被引：57

作者：

PETITET, F ^{[1
]}

BEAUJOUAN, JC ^{[1
]}

SAFFROY, M ^{[1
]}

TORRENS, Y ^{[1
]}

GLOWINSKI, J ^{[1
]}

机构：

[1] COLL FRANCE, CHAIR NEUROPHARMACOL, INSERM, U114, 11 PL MARCELIN BERTHELOT, F-75231 PARIS 05, FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 191卷 / 01期

关键词：

D O I：

10.1006/bbrc.1993.1200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SR 48968 was first described as a NK-2 nonpeptide receptor antagonist; we report here that SR 48968 interacts also with guinea pig but not rat NK-3 cortical binding sites. Furthermore, SR 48968 is shown to inhibit the senktide- (a NK-3 selective agonist) evoked stimulation of phosphoinositide turnover in guinea pig ileum slices. The species difference observed for the NK-3 receptor with SR 48968 was confirmed by the determination of the affinities of NK-3 peptide agonists. [Pro7]neurokinin B particularly was found to have a greater affinity for cortical NK-3 binding sites in the rat than in the guinea pig. © 1993 Academic Press.

引用

页码：180 / 187

页数：8

共 24 条

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