INTERLEUKIN-1-BETA INCREASES SYNAPTIC INHIBITION IN RAT HIPPOCAMPAL PYRAMIDAL NEURONS INVITRO

被引：71

作者：

ZEISE, ML ^{[1
]}

MADAMBA, S ^{[1
]}

SIGGINS, GR ^{[1
]}

机构：

[1] Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA USA

来源：

REGULATORY PEPTIDES | 1992年 / 39卷 / 01期

关键词：

CYTOKINE; GABA; INTERNEURONAL COMMUNICATION; INTRACELLULAR RECORDING; NEURONAL PLASTICITY; SYNAPTIC CONDUCTANCE;

D O I：

10.1016/0167-0115(92)90002-C

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interleukin-1 (IL-1), a cytokine with a broad spectrum of biological activity, modulates electrical properties of central neurons in the brain. The effects of IL-1-beta-(143 pM) on conductances opened by synaptic stimulation of the Schaffer collaterals were studied by intracellular recording of hippocampal pyramidal cells of the CA1 region. IL-1-beta enhanced and prolonged synaptic inhibition by about 2 to 3-fold. Heat-inactivated IL-1-beta had no effect. This finding implies that IL-1-beta changes interneuronal communication in the hippocampus with a possible impact on neuronal plasticity.

引用

页码：1 / 7

页数：7

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