EFFECTS OF MINIMALLY INVASIVE SURGERY ON HYPOCHLOROUS ACID PRODUCTION BY NEUTROPHILS

被引:33
作者
CAREY, PD [1 ]
WAKEFIELD, CH [1 ]
THAYEB, A [1 ]
MONSON, JRT [1 ]
DARZI, A [1 ]
GUILLOU, PJ [1 ]
机构
[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,ST MARYS HOSP,SCH MED,ACAD SURG UNIT,LONDON,ENGLAND
关键词
D O I
10.1002/bjs.1800810425
中图分类号
R61 [外科手术学];
学科分类号
摘要
The production of chlorinated oxidants such as hypochlorous acid is a central antimicrobial and immunoregulatory function of neutrophils. Neutrophil hypochlorous acid production was compared in patients undergoing uncomplicated laparoscopic surgery (group 1) and those submitted to conventional open surgery (group 2). Preoperative peak hypochlorous acid production was similar in the two groups (mean(s.e.m.) 0.60(0.05) versus 0.69(0.06) nmol/min respectively). In group 2, mean(s.e.m.) neutrophil hypochlorous acid production fell significantly on day 1 after surgery (0.36(0.05) nmol/min; P<0.01) but this did not occur in group 1 (0.63(0.07) nmol/min). By day 6 hypochlorous acid kinetics had returned to preoperative levels in both groups. Minimally invasive surgery is less disruptive of neutrophil function than conventional open procedures.
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收藏
页码:557 / 560
页数:4
相关论文
共 29 条
[11]  
FAIST E, 1986, ARCH SURG-CHICAGO, V121, P1000
[12]  
FAIST E, 1992, SURGERY, V112, P562
[13]   MONOCYTE HLA-DR ANTIGEN EXPRESSION CHARACTERIZES CLINICAL OUTCOME IN THE TRAUMA PATIENT [J].
HERSHMAN, MJ ;
CHEADLE, WG ;
WELLHAUSEN, SR ;
DAVIDSON, PF ;
POLK, HC .
BRITISH JOURNAL OF SURGERY, 1990, 77 (02) :204-207
[14]   METABOLIC AND RESPIRATORY CHANGES AFTER CHOLECYSTECTOMY PERFORMED VIA LAPAROTOMY OR LAPAROSCOPY [J].
JORIS, J ;
CIGARINI, I ;
LEGRAND, M ;
JACQUET, N ;
DEGROOTE, D ;
FRANCHIMONT, P ;
LAMY, M .
BRITISH JOURNAL OF ANAESTHESIA, 1992, 69 (04) :341-345
[15]   STIMULATED HUMAN-NEUTROPHILS DAMAGE CARDIAC SARCOPLASMIC-RETICULUM FUNCTION BY GENERATION OF OXIDANTS [J].
KUKREJA, RC ;
WEAVER, AB ;
HESS, ML .
BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 990 (02) :198-205
[16]   THE INFLUENCE OF SURGICAL OPERATIONS ON COMPONENTS OF THE HUMAN IMMUNE-SYSTEM [J].
LENNARD, TWJ ;
SHENTON, BK ;
BORZOTTA, A ;
WHITE, M ;
GERRIE, LM ;
PROUD, G ;
TAYLOR, RMR .
BRITISH JOURNAL OF SURGERY, 1985, 72 (10) :771-776
[17]  
McMahon AJ, 1993, BRIT J SURG, V80, P641
[18]   PHYSIOLOGICAL AND METABOLIC RESPONSES TO OPEN AND LAPAROSCOPIC CHOLECYSTECTOMY [J].
MEALY, K ;
GALLAGHER, H ;
BARRY, M ;
LENNON, F ;
TRAYNOR, O ;
HYLAND, J .
BRITISH JOURNAL OF SURGERY, 1992, 79 (10) :1061-1064
[19]   TUMOR NECROSIS FACTOR AND BACTERIAL SEPSIS [J].
MICHIE, HR ;
GUILLOU, PJ ;
WILMORE, DW .
BRITISH JOURNAL OF SURGERY, 1989, 76 (07) :670-671
[20]   PROSPECTIVE EVALUATION OF LAPAROSCOPIC-ASSISTED COLECTOMY IN AN UNSELECTED GROUP OF PATIENTS [J].
MONSON, JRT ;
DARZI, A ;
CAREY, PD ;
GUILLOU, PJ .
LANCET, 1992, 340 (8823) :831-833