TIME COURSE OF ALTERATIONS OF RAT LIVER POLYSOME PROFILES INDUCED BY AFLATOXIN B1

被引：21

作者：

PONG, RS

WOGAN, GN

机构：

[1] Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge

来源：

BIOCHEMICAL PHARMACOLOGY | 1969年 / 18卷 / 10期

关键词：

D O I：

10.1016/0006-2952(69)90350-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aflatoxin B1 administered intraperitoneally (i.p.) as a single dose to rats at a dose level of 3 mg/kg (the ld50) caused marked, but reversible, disaggregation of liver polysomes. Although disaggregation was not evident within 0.5 hr, it was extensive at 3 hr and persisted through 36 hr after dosing. Partial reaggregation began at 36 hr, and the process was essentially complete by 5 days after dosing. © 1969.

引用

页码：2357 / &

共 15 条

[11] AFLATOXIN B1 - BINDING TO DNA IN VITRO AND ALTERATION OF RNA METABOLISM IN VIVO
SPORN, MB
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WETTSTEIN, FO
NOLL, H
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[13] SVBODA D, 1966, AM J PATH, V49, P1023
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VILLATREVINO, S
LEAVER, DD
[J]. BIOCHEMICAL JOURNAL, 1968, 109 (01) : 87 - +
[15] INHIBITION BY AFLATOXIN B1 OF HYDROCORTISONE INDUCTION OF RAT LIVER TRYPTOPHAN PYRROLASE AND TYROSINE TRANSAMINASE
WOGAN, GN
FRIEDMAN, MA
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1968, 128 (02) : 509 - &

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