THE N-METHYL-D-ASPARTATE ANTAGONIST MK-801 FAILS TO PROTECT DOPAMINERGIC-NEURONS FROM 1-METHYL-4-PHENYLPYRIDINIUM TOXICITY INVITRO

被引：26

作者：

FINIELSMARLIER, F ^{[1
]}

MARINI, AM ^{[1
]}

WILLIAMS, P ^{[1
]}

PAUL, SM ^{[1
]}

机构：

[1] NIMH,CLIN NEUROSCI BRANCH,MOLEC PHARMACOL BRANCH,BLDG 10,ROOM 4N224,BETHESDA,MD 20892

来源：

JOURNAL OF NEUROCHEMISTRY | 1993年 / 60卷 / 05期

关键词：

1-METHYL-4-PHENYLPYRIDINIUM; MESENCEPHALIC CULTURES; DOPAMINERGIC NEURONS; N-METHYL-D-ASPARTATE RECEPTOR; MK-801;

D O I：

10.1111/j.1471-4159.1993.tb13431.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent reports suggest that NMDA receptor antagonists when administered in vivo can protect dopaminergic neurons from the toxic actions of MPP+. In the present study the possible neuroprotective effects against MPP+ toxicity of the noncompetitive NMDA receptor antagonist MK-801 was studied in primary cultures of fetal rat mesencephalic dopamine neurons. MK-801 failed to protect dopaminergic neurons from MPP+ toxicity at concentrations that completely block NMDA-induced toxicity of these same neurons. In contrast to work carried out in cerebellar granule cells, MPP+ toxicity of mesencephalic dopamine neurons was unaffected by preexposure to subtoxic concentrations of either NMDA or cycloheximide. Our findings suggest that the toxic effects of MPP+ on dopaminergic neurons are not mediated through a direct interaction with the NMDA subtype of glutamate receptor.

引用

页码：1968 / 1971

页数：4

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