REVIEW - MEDIATION OF THE OCULAR RESPONSE TO INJURY

被引：28

作者：

UNGER, WG

机构：

[1] Departments of Ophthalmology and Physiological Sciences, University of Manchester, Manchester Royal Eye Hospital, Manchester

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1990年 / 6卷 / 04期

关键词：

D O I：

10.1089/jop.1990.6.337

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The structures of the anterior segment of the eye provide aqueous humour for metabolic traffic, regulation of intraocular pressure and the maintenance of a functional permeability barrier to separate internal compartments from general systemic influences. Irritative and injurous insults to the eye elicit an acute defensive miotic and vascular response which upsets the aqueous dynamics and provokes the influx of blood plasma proteins into the aqueous chambers. These events are initiated by antidromic activation of sensory elements within the anterior segment, releasing substance P and calcitonin gene-related peptide (CGRP) which, in lower mammals at least, stimulate respectively the miotic and vascular reactions. Considerable species differences can be found in the responsiveness of the eye to injury and in the effects of exogenous CGRP and substance P.

引用

页码：337 / 353

页数：17

共 172 条

[1]

Cole D.F., Unger W.G., Prostaglandins as mediators for the response of the eye to trauma, Exp. Eye Res, 17, pp. 357-368, (1973)

[2]

Cole D.F., Unger W.G., Action of bradykinin on intraocular pressure and pupil diameter, Ophthalmic Res, 6, pp. 308-314, (1974)

[3]

Bito L.Z., The effects of experimental uveitis on anterior uveal prostaglandin transport and aqueous humour composition, Invest. Ophthalmol, 13, pp. 959-966, (1974)

[4]

Unger W.G., Perkins E.S., Bass M.S., The response of the rabbit eye to laser irradiation of the iris, Exp. Eye Res, 19, pp. 367-377, (1974)

[5]

Unger W.G., Hammond B.R., Cole D.F., Disruption of the blood-aqueous barrier following paracentesis in the rabbit, Exp. Eye Res, 20, pp. 255-270, (1975)

[6]

Unger W.G., Cole D.F., Bass M.S., Prostaglandin and neurogenically mediated ocular response to laser irradiation of the rabbit iris, Exp. Eye Res, 25, pp. 209-220, (1977)

[7]

Jampol L.M., Neufeld A.H., Sears M.L., Pathways for the response of the eye to injury, Invest. Ophthalmol, 14, pp. 184-189, (1975)

[8]

Jampol L.M., Axelrod A., Tessler H., Pathways of the eye's response to topical nitrogen mustard, Invest. Ophthalmol, 15, pp. 486-489, (1976)

[9]

Eakins K.E., Prostaglandin and non-prostaglandin mediated breakdown of the blood-aqueous barrier, Exp. Eye Res, 25, pp. 483-498, (1977)

[10]

Kottow M., Anterior segment reactions after experimental trauma to rabbit eyes, Graefes Archiv. Ophthalmol, 209, pp. 125-135, (1979)

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