REVIEW - MEDIATION OF THE OCULAR RESPONSE TO INJURY

被引：28

作者：

UNGER, WG

机构：

[1] Departments of Ophthalmology and Physiological Sciences, University of Manchester, Manchester Royal Eye Hospital, Manchester

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1990年 / 6卷 / 04期

关键词：

D O I：

10.1089/jop.1990.6.337

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The structures of the anterior segment of the eye provide aqueous humour for metabolic traffic, regulation of intraocular pressure and the maintenance of a functional permeability barrier to separate internal compartments from general systemic influences. Irritative and injurous insults to the eye elicit an acute defensive miotic and vascular response which upsets the aqueous dynamics and provokes the influx of blood plasma proteins into the aqueous chambers. These events are initiated by antidromic activation of sensory elements within the anterior segment, releasing substance P and calcitonin gene-related peptide (CGRP) which, in lower mammals at least, stimulate respectively the miotic and vascular reactions. Considerable species differences can be found in the responsiveness of the eye to injury and in the effects of exogenous CGRP and substance P.

引用

页码：337 / 353

页数：17

共 172 条

[51]

Edwards J.E., A new apparatus for fluorescein angiography of the anterior segment of the eye, J. Physiol. (Lond.), 246, pp. 39-40P, (1974)

[52]

Bhattacher jee P.G., Hammond B.R., Inhibition of increased permeabillity of the blood-aqueous barrier by non-steroidal anti-inflammatory compounds, Exp. Eye Res, 21, pp. 499-505, (1975)

[53]

Whitelocke R.A.F., Eakins K.E., Vascular changes in the anterior uvea of the rabbit produced by prostaglandins, Arch. Ophthalmol, 89, pp. 495-499, (1973)

[54]

Laties A.M., Neufeld A.H., Vegge T., Sears M.L., Differential reactivity of rabbit iris and ciliary processes to topically applied prostaglandin E2 (dinoprostone), Arch. Ophthalmol, 94, pp. 1966-1971, (1976)

[55]

Klein E.M., Bito L.Z., Species variations in the pathophysiologic responses of vertebrate eyes to chemical irritant, nitrogen mustard, Invest. Ophthalmol, 24, pp. 184-191, (1983)

[56]

Unger W.G., Brown N.A.P., Edwards J., The response of the human eye to laser irradiation of the iris, Br. J. Ophthalmol, 61, pp. 148-153, (1977)

[57]

Bito L.Z., Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds, Exp. Eye Res, 38, pp. 181-194, (1984)

[58]

Raviola G., Raviola E., Intercellular junctions in the ciliary epithelium of the rhesus monkey, Anat. Rec, 181, (1975)

[59]

Bartels S.P., Pederson J.E., Gaasterland D.E., Armaly M.F., Sites of breakdown of the blood-aqueous barrier after paracentesis of the rhesus monkey eye, Invest. Ophthalmol, 18, pp. 1050-1060, (1979)

[60]

Ambache N., Kavanagh L., Whiting J., Effect of mechanical stimulation on rabbit's eyes

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