AFFINITY DISTRIBUTIONS OF ANTIGEN-SPECIFIC IGG IN PATIENTS WITH MULTIPLE-SCLEROSIS AND IN PATIENTS WITH VIRAL ENCEPHALITIS

被引：43

作者：

LUXTON, RW

THOMPSON, EJ

机构：

[1] Department of Special Chemical Pathology, Institute of Neurology, National Hospitals for Nervous Diseases, London, WC1 3BG, 9th Floor, Queen Square

来源：

JOURNAL OF IMMUNOLOGICAL METHODS | 1990年 / 131卷 / 02期

关键词：

Affinity; Multiple sclerosis; Specific IgG;

D O I：

10.1016/0022-1759(90)90199-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We report a method for displaying the affinity distribution of a polyclonal antibody population using sodium thiocyanate elution followed by an ELISA detection technique. We have used this method to study the affinity distribution of antibodies in samples of CSF and serum from patients with MS, and compared the results to those obtained from patients with viral encephalitis. Patients with MS had predominately low affinity antibody against a particular antigen whilst patients with a primary viral infection had predominantly high affinity antibody against the causative organism. © 1990.

引用

页码：277 / 282

页数：6

共 14 条

[11]

Underwood P A, 1988, Adv Virus Res, V34, P283, DOI 10.1016/S0065-3527(08)60521-7

[12] PROGRESSIVE RUBELLA-VIRUS PANENCEPHALITIS - SYNTHESIS OF OLIGOCLONAL VIRUS-SPECIFIC IGG ANTIBODIES AND HOMOGENEOUS FREE LIGHT-CHAINS IN CENTRAL NERVOUS-SYSTEM [J].

VANDVIK, B ;

WEIL, ML ;

GRANDIEN, M ;

NORRBY, E .

ACTA NEUROLOGICA SCANDINAVICA, 1978, 57 (01) :53-64

[13] VIRAL AND BACTERIAL ANTIBODY-RESPONSES IN MULTIPLE-SCLEROSIS [J].

VARTDAL, F ;

VANDVIK, B ;

NORRBY, E .

ANNALS OF NEUROLOGY, 1980, 8 (03) :248-255

[14]

WERBLIN TP, 1973, IMMUNOLOGY, V24, P477

← 1 2 →