BIOMIMETIC SYNTHESIS OF PYRIDO[2,3,4-KL]ACRIDINES

被引：20

作者：

GELLERMAN, G ^{[1
]}

RUDI, A ^{[1
]}

KASHMAN, Y ^{[1
]}

机构：

[1] TEL AVIV UNIV,SCH CHEM,IL-69978 TEL AVIV,ISRAEL

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 11期

关键词：

D O I：

10.1016/S0040-4039(00)60789-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short new biomimetic route to the pyrido[2,3,4-kl]acridine ring system has been developed from readily available benzoquinone, or hydroquinone precursors, and beta,beta'-diaminoketones like kynuramine (3) or 2,2'-diaminobenzophenone (4), involving one key step. Pyrido[2,3,4-kl]acridine and closely related compounds have been prepared (5-9). The reaction has been shown to proceed to the formation of 1:1 and/or 1:2 quinone/amine adducts. Using of o-aminoacetophenone afforded dibenzo[1,10]phenanthrolinedione (11) a potential intermediate to eilatin 2.

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页码：1823 / 1826

页数：4

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