ISOLATION OF 2R,5R-DIHYDROXYMETHYL-3R,4R-DIHYDROXYPYRROLIDINE (DMDP) FROM THE FERMENTATION BROTH OF STREPTOMYCES SP, KSC-5791

被引：12

作者：

WATANABE, S

KATO, H

NAGAYAMA, K

ABE, H

机构：

[1] Life science Research Institute, Kumiai Chemical Industry Co., Ltd., Shizuoka 439, 3360 Kikugawa-cho, Ogasa-cho

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1995年 / 59卷 / 05期

关键词：

D O I：

10.1271/bbb.59.936

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Isolation of 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP, 1) was isolated from the fermentation broth of Streptomyces sp, KSC-5791 by chromatographic techniques including preparative HPLC in a Shodex Asahipak NH2P-50 column. Compound 1 inhibited trehalases of Corynebacterium sp.(1)) and diamondback moth (Plutella xylostella), but did not inhibit porcine kidney trehalase.

引用

页码：936 / 937

页数：2

共 15 条

[1] BLANEY WM, 1984, ENTOMOL EXP APPL, V36, P209, DOI 10.1007/BF00185649
[2] BRASSEUR PJL, 1977, ACTA CRYSTALLOGR B, V33, P409
[3] SYNTHESIS OF 2(R),5(R)-BIS(HYDROXYMETHYL)-3(R),4(R)-DIHYDROXYPYRROLIDINE - A NOVEL GLYCOSIDASE INHIBITOR
CARD, PJ
HITZ, WD
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (06) : 891 - 893
[4] ELBEIN AD, 1984, J BIOL CHEM, V259, P2409
[5] GLYCOSIDASE INHIBITION BY PLANT ALKALOIDS WHICH ARE STRUCTURAL ANALOGS OF MONOSACCHARIDES
EVANS, SV
FELLOWS, LE
SHING, TKM
FLEET, GWJ
[J]. PHYTOCHEMISTRY, 1985, 24 (09) : 1953 - 1955
[6] MORANOLINE (1-DEOXYNOJIRIMYCIN) FERMENTATION AND ITS IMPROVEMENT
EZURE, Y
MARUO, S
MIYAZAKI, K
KAWAMATA, M
[J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1985, 49 (04): : 1119 - 1125
[7] ENANTIOSPECIFIC SYNTHESES OF DEOXYMANNOJIRIMYCIN, FAGOMINE AND 2R,5R-DIHYDROXYMETHYL-3R,4R-DIHYDROXYPYRROLIDINE FROM D-GLUCOSE
FLEET, GWJ
SMITH, PW
[J]. TETRAHEDRON LETTERS, 1985, 26 (11) : 1469 - 1472
[8] NOVEL MANNOSIDASE INHIBITOR BLOCKING CONVERSION OF HIGH MANNOSE TO COMPLEX OLIGOSACCHARIDES
FUHRMANN, U
BAUSE, E
LEGLER, G
PLOEGH, H
[J]. NATURE, 1984, 307 (5953) : 755 - 758
[9] ALPHA-HOMONOJIRIMYCIN AND 2,5-DIHYDROXYMETHYL-3,4-DIHYDROXY-PYRROLIDINE - ALKALOIDAL GLYCOSIDASE INHIBITORS IN THE MOTH URANIA-FULGENS
KITE, GC
HORN, JM
ROMEO, JT
FELLOWS, LE
LEES, DC
SCOFIELD, AM
SMITH, NG
[J]. PHYTOCHEMISTRY, 1990, 29 (01) : 103 - 105
[10] ALKALOIDAL GLYCOSIDASE INHIBITORS IN NOCTURNAL AND DIURNAL URANIINE MOTHS AND THEIR RESPECTIVE FOODPLANT GENERA, ENDOSPERMUM AND OMPHALEA
KITE, GC
FELLOWS, LE
LEES, DC
KITCHEN, D
MONTEITH, GB
[J]. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 1991, 19 (06) : 441 - 445

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