A FORMAL TOTAL SYNTHESIS OF (+/-)-PSEUDOMONIC ACID-A

被引:12
作者
CLASS, YJ [1 ]
DESHONG, P [1 ]
机构
[1] UNIV MARYLAND,DEPT CHEM & BIOCHEM,COLLEGE PK,MD 20742
基金
美国国家卫生研究院;
关键词
D O I
10.1016/0040-4039(95)01590-E
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The pyran nucleus pseudomonic acid A has been prepared via a furan oxidation strategy. Introduction of the C-8 sidechain (pseudomonic acid numbering) was accomplished regio- and stereoselectively by either the Johnson variation of the Claisen rearrangement or by Pd-catalyzed allylic displacement.
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页码:7631 / 7634
页数:4
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