KNOWLEDGE OF CELLULAR RECEPTORS FOR BACTERIAL-ENDOTOXIN - 1995

被引:24
作者
VIRIYAKOSOL, S
KIRKLAND, T
机构
[1] UNIV CALIF SAN DIEGO,SCH MED,DEPT PATHOL,SAN DIEGO,CA 92103
[2] UNIV CALIF SAN DIEGO,SCH MED,DEPT MED,SAN DIEGO,CA 92103
[3] VET AFFAIRS MED CTR,SAN DIEGO,CA 92161
关键词
D O I
10.1093/clinids/21.Supplement_2.S190
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Septic shock due to infections with gram-negative bacteria remains a major clinical problem for infectious disease specialists, although our understanding of the pathophysiology of this syndrome has improved greatly over the past 5 years. The discovery of lipopolysaccharide (LPS) binding protein, a serum protein that catalyses the transfer of LPS to cellular receptors for LPS, was a major breakthrough. The finding that CD14, a glycophosphatidylinositol-linked membrane protein expressed by macrophages, is a receptor for LPS has made a major difference in our understanding of cellular activation by LPS. We will review studies dealing with LPS's binding to these proteins and its activation of cells. A better understanding of septic shock at the molecular level should lead to the development of new treatments for this lethal disease.
引用
收藏
页码:S190 / S195
页数:6
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